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Jacob, Kristin

Department of Microbiology & Molecular Genetics
6107 Biomedical Physical Sciences
Michigan State University
East Lansing, MI 48824
(517) 884-5370




Kristin Jacob is a Ph.D. candidate in the lab of Dr. Gemma Reguera whose research interests are focused in microbial pathogenesis, molecular microbiology, natural products and the microbiome. Her current research focuses on studying the microbiome of the middle ear. As part of a larger DoD funded project, she aims to identify the native community of the middle ear microbiome, with special interest in exploring the community differences between divers and non-divers and identify those with highest potential for development of bacterial replacement therapies targeting the prevention/treatment of barotrauma in divers. Presentation of her research at the 2019 SIMB Annual Meeting earned the Best Student Poster award in the Natural Products division of the conference. Kristin earned her B.S. in Biology, with a concentration in microbiology, and a M.Sc. in Biology at Northern Michigan University where her research focused on studying the role a novel two-component system played in virulence of Pseudomonads and compared its role in a homologous system in Vibrio cholerae. Prior to starting her doctoral program, she continued her research focus in bacterial pathogenesis as a research technician at the University of Michigan, where she studied gene regulation in Group A Streptococcus. Outside of the lab, Kristin actively participates in outreach programs through various on campus organizations and promotes graduate student and post-doc engagement in social and professional development programs/workshops through her position in the Michigan chapter of Graduate Women in Science (GWIS).



  1. Nye TM, Jacob KM, Holley EK., Nevarez JM., Dawid SR., Simmons LA., & Watson Jr. ME. 2019. DNA methylation from a type I restriction modification system influences gene expression & virulence in Streptococcus pyogenes. PLoS Pathogens. 15(6):e1007841.
  2. Jacob KM, Rasmussen A, Tyler P, Servos MM, Sylla M, Prado C, Daniele E, Purdy AE, & Sharp JS. 2017. Regulation of acetyl-CoA synthetase transcription by CrbS/R homologs is conserved in genetically diverse environmental pathogens. PLOS ONE 12(5):e0177825.
  3. Jacob KM, Spilker T, LiPuma JJ, Dawid SR, Watson ME, Jr. 2016. Complete genome sequence of emm28 type Streptococcus pyogenes MEW123, a streptomycin-resistant derivative of a clinical throat isolate suitable for investigation of pathogenesis. Genome Announc 4(2):e00136-16.
  4. Jacob KM, Spilker T, LiPuma JJ, Dawid SR, Watson ME, Jr. 2016. Complete genome sequence of emm4 Streptococcus pyogenes MEW427, a throat isolate from a child meeting clinical criteria for pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS). Genome Announc 4(2):e00127-16. doi:10.1128/genomeA.00127-16.
  5. Jacob KM, (2015) Gene regulation by a novel two-component system conserved among gammaproteobacteria. NMU Master’s Thesis.


Poster Presentations:

  1. Jacob KM, Lee JY, Reguera G. (2019). Otic microbiome engineering for prevention of barotrauma in divers. 70th Annual Meeting - Society for Industrial Microbiology and Biotechnology. Washington, DC.
  2. Saluzzo J, Jacob KM, Mueller EA, Dawid SR, & Watson ME. (2016). Environmental Conditions Regulate the Expression of the Streptococcus pyogenes R28 Surface Protein Promoting Colonization in the Female Genital Tract. Conference on Streptococcal Genetics – American Society for Microbiology. Washington, DC.
  3. Jacob KM, Laczkovich IL, Ahmed S, Dawid SR, & Watson ME. (2016). Mutations Inactivating the Streptococcus pyogenes Multiple Gene Regulator Decrease Host Inflammatory Responses & Promote Persistent Mucosal Carriage. 1st Microbe Meeting – American Society for Microbiology. Boston, MA.
  4. Jacob KM, Sharp JS & Purdy A. (2014). Deletion of a conserved two-component system in Pseudomonas entomophila results in altered pigment production & reduced virulence in a Drosophila model of infection. 114th General Meeting - American Society for Microbiology. Boston, MA.
  5. Jacob KM, Sharp JS & Purdy A. (2013). Gene regulation of a novel two-component system in Pseudomonas entomophila. American Society for Microbiology –Michigan Branch Fall Meeting. Bay City, MI.