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Hsueh, Brian

Department of Microbiology & Molecular Genetics
5120 Biomedical Physical Sciences
Michigan State University
East Lansing, MI 48824
(517) 884-5336




Brian Hsueh is a third-year PhD student in Dr. Christopher Waters lab. Brian’s main research interest is to uncover the biological functions of novel second messenger signaling system in bacteria. His dissertation project focuses on the potential second messenger molecule via Erwinia amylovora, the causative agent of plant disease Fire Blight, to uncover novel pathway that associates second messenger signaling and pathogenesis. Hsueh received his B.S. at the University of Michigan, Ann Arbor in Microbiology. As part of his undergraduate research in Dr. Robert Fuller lab, Hsueh worked on several projects involved with understanding the cell trafficking in baker’s yeast Saccharomyces cerevisiae and other important gene regulation and target genes that are associated with Huntington-like neurogenerative diseases in humans. Outside of research, Brian enjoys golfing and hiking in the summer and cross-country skiing in the winter.


1. Hsueh, B. Y., & Waters, C. M. (2019). Combating Cholera. F1000Research, 8, F1000 Faculty Rev-589. doi:10.12688/f1000research.18093.1


1. MMPC Annual Meeting, 2018 – Poster Presentation – Regulation of HrpS by the breakdown product of cyclic di-GMP controls Type III Secretion in Erwinia amylovora

2. ASBMB Symposium: Evolution and Core Processes in Gene Expression, 2019—Poster Presentation – The cyclic di-GMP degradation product pGpG activates virulence in Erwinia amylovora

3. Wind River Conference Annual Meeting, 2019 – Oral Presentation—Potential Second Messenger pGpG Activates T3SS Through HrpS in Erwinia amylovora

4. MMPC Annual Meeting, 2019 – Poster Presentation—The cyclic di-GMP degradation product pGpG activates virulence in Erwinia amylovora

5. BEACON Seminar, 2019 – Oral Presentation—Yin and Yang: Combining bioinformatics and wet-lab experiments to explore horizontally transferred genes in Vibrio cholerae