Department of Microbiology & Molecular Genetics
5105 Biomedical Physical Sciences
Michigan State University
East Lansing, MI 48824
Lucas Demey is a 4th year graduate student pursuing his PhD in Microbiology and Molecular genetics. Lucas is interested in understanding virulence gene regulation in bacterial pathogens and identifying compounds that perturb these regulatory networks. As a member of the DiRita lab, he is using classic genetic, biochemical, biophysical and chemical biology approaches to better understand the virulence cascade in Vibrio cholerae. Lucas’ work is focused on gaining a deeper understanding of post-translational regulation of TcpP, a positive regulator virulence, and its single molecule dynamics through a collaboration with the Biteen lab at the University of Michigan. In addition, Lucas is also interested in characterizing the mechanism of action of small molecules that inhibit virulence in V. cholerae. Lucas received his B.S. in Microbiology from Michigan State University. As an undergraduate student, Lucas worked in the Kashefi lab were he studied novel marine hyperthermophiles, Pyrodictium delaneyi strain Hulk and Pyrodictium barossii using computational approaches.
1) Demey LM, Miller CR, Manzella MP, Spurbeck RR, Sandhu SK, Reguera G, Kashefi K. The draft genome of the hyperthermophilic archaeon Pyrodictium delaneyi strain hulk, an iron and nitrate reducer, reveals the capacity for sulfate reduction. Standards in genomic sciences. 2017 Dec;12(1):47.
2) Karslake J, Donarski ED, Shelby SA, Demey LM, DiRita VJ, Veatch SL, Biteen JS. SMAUG: Analyzing single-molecule tracks with nonparametric Bayesian statistics. bioRxiv. 2019 Jan 1:578567.