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Dechow, Shelby

Address:
Department of Microbiology & Molecular Genetics
5118 Biomedical Physical Sciences
Michigan State University
East Lansing, MI 48824
(517) 884-5363
dechowsh@msu.edu

 

 


Shelby Dechow is a fourth-year Ph.D. student in the Microbiology and Molecular Genetics (MMG) Department where she pursues her interests in infectious diseases and microbial genetics. As a member of the Abramovitch Lab, she is researching how Mycobacterium tuberculosis (Mtb) adapts to environmental cues and determining novel therapeutics drugs that inhibit its survival and proliferation in the human body. Her thesis research focuses on understanding and studying the underlying mechanisms behind Mtb’s adaptation to acidic pH – a hallmark of its host niches, the macrophage and necrotic granuloma. Shelby has received competitive funding through a T32 training grant from NIGMS whereby she has expanded her technical knowledge and skills in in vivo pharmacological techniques and drug discovery. In addition, Shelby is an active member of the MMG Department where she has participated in graduate student recruitment weekends, volunteered for MSU Science Festival, planned the annual MMG Welcome Picnic, and served as graduate student representative for faculty meetings and curriculum committee. Shelby earned a B.S. in Biotechnology and a B.A. in Foreign Languages from the University of Nebraska Omaha where she studied genes responsible for septin regulation in the pathogenic yeast, Candida albicans. Shelby’s first experiences with scientific research was in infectious human diseases, and since then she has made it her overarching goal to investigate the mechanisms that human pathogens use to establish and maintain infections. She envisions herself fulfilling this goal as a staff scientist for a government agency.

Publications:

  1. Baker, J, Dechow, S, Abramovitch, R. 2019. Acid Fasting: Modulation of Mycobacterium tuberculosis Metabolism at Acidic pH. Trends Microbiol 27: 942–53
  2. Abeli, P*, Dechow, S*, Gottschalk, C*, Williams, J*. (forthcoming) Peppered Moths and the Mutation Mechanisms of Transposons. In D. Ebert-May and E. Holt (Eds.), Pathways to Scientific Teaching. New York, NY: W.H. Freeman. *Co-authors contributed equally

Presentations:

  1. Dechow, S, Coulson, G, and Abramovitch, R. Understanding the genetic and chemical biology of pH-driven adaptation in Mycobacterium tuberculosis. MSU Council of Graduate Student Graduate Academic Conference; 2018 February; East Lansing, MI.
  2. Dechow S, Coulson, G, and Abramovitch, R. Understanding the genetic and chemical biology of pH-driven adaptation in Mycobacterium tuberculosis. IPSTP Retreat; 2018 February; East Lansing, MI.
  3. Dechow S, Coulson, G, and Abramovitch, R. Chemical probes targeting Mycobacterium tuberculosis pH-driven adaptation. Keystone Symposium on Tuberculosis: Translating Scientific Findings for Clinical and Public Health Impact; 2018 April; Whistler, British Columbia, Canada.
  4. Dechow, S, Coulson, G, and Abramovitch, R. Chemical probes targeting Mycobacterium tuberculosis pH-driven adaptation. Phi Zeta Research Day; October 2018, East Lansing, MI.
  5. Dechow, S, Baker, J, and Abramovitch, R. Mutations in ppe51 enable M. tuberculosis growth in acidic environments that normally promote nonreplicating persistence. Keystone Symposium on Tuberculosis: Mechanisms, Pathogenesis and Treatment; 2019 January; Banff, Alberta, Canada.
  6. Dechow, S, Coulson, G, and Abramovitch, R. Chemical probes targeting Mycobacterium tuberculosis pH-driven adaptation. IPSTP Retreat; 2019 March; East Lansing, MI.