Crosson, Sean

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New Faculty - June 2019

Sean Crosson
Rudolph Hugh Endowed Professor
B.A.
, 1996, Earlham College
Ph.D., 2002, University of Chicago
Post-doctoral studies, 2003-2005, Stanford University School of Medicine

 crosson4@msu.edu

Overview of research program

Our group investigates the molecular basis of environmental adaptation in bacteria that inhabit niches ranging from freshwater, to soil, to the interior of mammalian cells. We utilize a cross-disciplinary set of experimental and computational tools to understand regulatory mechanisms that enable bacterial cells to adapt their physiology to changing environments.

Our studies primarily center on Alphaproteobacteria including mammalian pathogens of the genus Brucella, the freshwater and soil bacterium Caulobacter crescentus, and the marine photoheterotroph Erythrobacter litoralis. Research in the lab includes:

1) Functional, structural, and biophysical characterization of light/redox protein sensors
2) Genetic and structural studies of cell adhesion and cell cycle control systems
3) Structural, functional, and computational studies of the alphaproteobacterial general stress signaling system, including its role in chronic brucellosis

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